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Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies


Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to the non-accurate pre-clinical models that are being currently used for drug development and in personalised therapies. To ensure that the assessment of drug efficacy and their mechanism of action have clinical translatability, the complexity of the tumor microenvironment needs to be properly modelled. 3D culture models are emerging as a powerful research tool that recapitulates in vivo characteristics. Technological advancements in this field show promising application in improving drug discovery, pre-clinical validation, and precision medicine. In this review, we discuss the significance of the tumor microenvironment and its impact on therapy success, the current developments of 3D culture, and the opportunities that advancements that in vitro technologies can provide to improve cancer therapeutics.

Type Journal
ISBN 2234-943X (Print) 2234-943X (Linking)
Authors Law, A. M. K.; Rodriguez de la Fuente, L.; Grundy, T. J.; Fang, G.; Valdes-Mora, F.; Gallego-Ortega, D.
Responsible Garvan Author Dr David Gallego-Ortega
Publisher Name Frontiers in Oncology
Published Date 2021-11-30
Published Volume 11
Published Pages 782766
Status Published in-print
DOI 10.3389/fonc.2021.782766
URL link to publisher's version