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Profile of dyslipidemia in Psammomys obesus, an animal model of the metabolic syndrome

Abstract

OBJECTIVE: To investigate lipid profiles in Psammomys obesus and relationships between lipid profile and other components of the Metabolic Syndrome. METHODS: A total number of 49 adults with a wide range of body weight and glucose tolerance were studied in a cross-sectional analysis. Plasma cholesterol distribution profiles were measured by size exclusion lipid chromatography. Blood glucose was measured using an enzymatic glucose analyser, and plasma insulin was determined by radioimmunoassay. RESULTS: Obese diabetic Psammomys obesus had elevated plasma cholesterol (P=0.003) and triglyceride levels (p>0.001) compared to their lean littermates. The hypercholesterolemia was mainly due to increased circulating levels of VLDL-cholesterol (P=0.003) and LDL-cholesterol (P=0.003) in these animals. Multiple linear regression analyses revealed that body weight was independently associated with plasma cholesterol (P=0.011) and LDL concentration (P=0.009), while plasma insulin was associated with VLDL-cholesterol concentration (P=0.005). All of the variables measured exhibited continuous distributions across a wide range of phenotypes, from a normal rodent lipid profile to profound dyslipidemia. CONCLUSIONS: These data suggest that the dyslipidemia in obese, diabetic Psammomys obesus is closely associated with other components of the Metabolic Syndrome, including obesity and insulin resistance.

Type Journal
ISBN 1210-0668 (Print)
Authors Walder, K.;Oakes, N.;Fahey, R. P.;Cooney, G.;Zimmet, P. Z.;Collier, G. R. :
Garvan Authors Prof Gregory Cooney
Publisher Name Endocr Regul
Published Date 2002-01-01 00:00:00
Published Volume 36
Published Issue 1
Published Pages 1-8
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11971745
Status Published In-print