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Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility


Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility.

Type Journal
ISBN 2589-0042 (Electronic) 2589-0042 (Linking)
Authors Woodhouse, R. M.; Frolows, N.; Wang, G.; Hawdon, A.; Wong, E. H. K.; Dansereau, L. C.; Su, Y.; Adair, L. D.; New, E. J.; Philp, A. M.; Tan, W. K.; Philp, A.; Ashe, A.
Publisher Name iScience
Published Date 2022-12-22
Published Volume 25
Published Issue 12
Published Pages 105573
Status Published in-print
DOI 10.1016/j.isci.2022.105573
URL link to publisher's version