Flexor reflex excitability in mice lacking galanin receptor galanin-R1
This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor. Repetitive stimulation of C-fibers induced a gradual increase in reflex magnitude during the stimulation (wind-up), and a subsequent increase in spinal reflex excitability (central sensitization). This occurred in GAL-R1 -/-, GAL-R1 +/-, and +/+ wild-type controls, with no significant differences observed between genotypes. Intrathecal administration of galanin markedly blocked the sensitization following the repetitive stimulation in all three groups. No differences between wild-type or galanin-R1 receptor knockout mice were seen. These results confirm previous studies in rats, showing that intrathecal galanin reduces the central sensitization following wind-up. The present data indicate that this effect is probably mediated by receptors other than GAL-R1.
|Authors||Grass, S.;Jacoby, A. S.;Iismaa, T. P.;Crawley, J. N.;Xu, X. J.;Wiesenfeld-Hallin, Z. :|
|Publisher Name||NEUROSCI LETT|
|Published Date||2003-01-01 00:00:00|