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The TNF family members BAFF and APRIL: the growing complexity


B cell activating factor belonging to the TNF family (BAFF) and apoptosis-inducing ligand (APRIL) are two related members of the TNF ligand superfamily. Although they share two receptors, TACI and BCMA, transgenic and knockout mice in this system reveal that their functions are not redundant. BAFF is a critical survival/maturation factor for peripheral B cells and this activity is mediated through a BAFF-specific receptor, BAFF-R. Overexpression of BAFF has been linked to autoimmune disease and aspects of B cell neoplasia. APRIL appears to play a role in T-independent type II antigen responses and T cell survival, but can also induce proliferation/survival of non-lymphoid cells. Elevated expression of APRIL has been found in some tumor cell lines and in tumor tissue libraries. Therapies designed to inhibit the BAFF and APRIL pathways holds great promise for the future.

Type Journal
ISBN 1359-6101 (Print)
Authors Mackay, F.;Ambrose, C. :
Publisher Name Cytokine Growth Factor Rev
Published Date 2003-01-01
Published Volume 14
Published Issue 3-4
Published Pages 311-24
Status Published in-print
URL link to publisher's version