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Complement in the induction of IgE antibody formation

Abstract

The IgE antibody response of NIH mice to ovalbumin was suppressed by in vivo complement depletion with cobra factor. This observation extends to IgE the finding that complement participates in thymus-dependent antibody formation. Control mice producing IgI anti-ovalbumin antibody after boosting all developed marked peripheral eosinophilia, whereas mice in which the IgE antibody response had been suppressed by cobra factor did not. Administration of cobra factor itself had no effect on peripheral eosinophil levels.

Type Journal
ISBN 0009-9104 (Print)
Authors Pepys, M. B.;Brighton, W. D.;Hewitt, B. E.;Bryant, D. E.;Pepys, J. :
Publisher Name CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Published Date 1977-01-01
Published Volume 27
Published Issue 3
Published Pages 397-400
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=862228
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/177