Publications

Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers

Abstract

Signaling through the B cell antigen receptor promotes activation and survival of mature B cells. B cell-activating factor belonging to the tumor necrosis factor family (BAFF) is another critical survival factor for B cells, and is also necessary for B cell maturation. Abnormal production of BAFF disturbs immune tolerance by allowing the survival of autoreactive B cells, thus triggering autoimmune disorders. BAFF can also have an important impact on B cell malignancies. In contrast to normal B cells, malignant B cells show uncontrolled cell proliferation. BAFF levels are elevated in the serum of patients with systemic autoimmune diseases, and, importantly, in patients with B-lymphoid malignancies. Furthermore, BAFF is produced by malignant B cells and acts as an essential autocrine survival factor. The strong dependence of certain lymphoid cancer cells on BAFF might be a point of vulnerability, which offers exciting new therapeutic possibilities.

Type Journal
ISBN 1471-4892 (Print)
Authors Mackay, F.;Tangye, S. G. :
Publisher Name CURRENT OPINION IN PHARMACOLOGY
Published Date 2004-01-01
Published Volume 4
Published Issue 4
Published Pages 347-54
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15251127
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/1819