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Circulating thyroid hormone levels and adequacy of dialysis


In vitro thyroid function tests were performed in three groups of patients with chronic renal failure who were receiving, on average, 15, 18 and 27 hours of maintenance hemodialysis per week. Total thyroxine levels were low and total triiodothyronine levels low to normal in those receiving the least dialysis (15 hours), and were significantly higher in those receiving longer dialysis. Free thyroxine levels, as measured by the effective thyroxine ratio, were normal and similar in all three groups, as were serum thyrotrophin levels. All patients were clinically euthyroid. As total hormone levels showed a significant inverse relationship to both urea and creatinine, this study suggests that there is a dialyzable metabolite retained in uremia which competes with thyroid hormones for protein-binding sites.

Type Journal
ISBN 0301-0430 (Print)
Authors Savdie, E.;Stewart, J. H.;Mahony, J. F.;Hayes, J. M.;Lazarus, L.;Simons, L. A. :
Publisher Name CLIN NEPHROL
Published Date 1978-01-01 00:00:00
Published Volume 9
Published Issue 2
Published Pages 68-72
Status Published In-print