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CCL3L1 dose and HIV-1 susceptibility


Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study reported on what could be a particularly important genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immune responses.

Type Journal
ISBN 1471-4914 (Print)
Authors Mackay, C. R. :
Publisher Name TRENDS MOL MED
Published Date 2005-01-01 00:00:00
Published Volume 11
Published Issue 5
Published Pages 203-6
Status Published In-print