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Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance


Isoforms of the protein kinase C family are strong candidates for mediating the inhibitory effects of lipid oversupply on insulin action. These enzymes are lipid-activated, can interfere with insulin signal transduction, and several studies have highlighted an association between insulin resistance and chronic activation of specific protein kinase C isoforms, especially epsilon (var epsilon) and theta (??). The assessment of glucose homeostasis and lipid-induced insulin resistance in protein kinase C ?? knockout mice has now demonstrated a key role for this isoform, although it is not yet clear whether its long-term inhibition would be beneficial. Potential approaches to block the action of specific PKC isoforms include pharmacological inhibitors, antisense oligonucleotides and bioactive peptides.

Type Journal
Authors Schmitz-Pfeiffer, C. :
Publisher Name Drug Discovery Today: Therapeutic Strategies
Published Date 2005-01-01 00:00:00
Published Volume 2
Published Pages 105-110
Status Published In-print