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Distinction at the leading edge of the cell


Cell locomotion is governed by spatially and temporally co-ordinated changes in the organization of the actin cytoskeleton. In the highlighted manuscript,((1)) the authors focus on actin remodelling at the front of moving cells to reveal the existence of two distinct yet spatially overlapping actin networks that play largely independent yet fundamental roles in cell migration. The first is defined as the lamellipodium, which assembles and disassembles within the first 3 microm of the leading edge. This serves to promote the random protrusion and retraction of the leading edge but has no role in productive cell translocation. The second actin network, the lamella, is responsible for the advancement of the cell by integrating contraction with cellular adhesions.

Type Journal
ISBN 0265-9247 (Print)
Authors Timpson, P.;Daly, R. J. :
Responsible Garvan Author (missing name)
Publisher Name BIOESSAYS
Published Date 2005-01-01
Published Volume 27
Published Issue 4
Published Pages 349-52
Status Published in-print
URL link to publisher's version