Follicular B helper T cells in antibody responses and autoimmunity
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4(+) T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.
|Authors||Vinuesa, C. G.;Tangye, S. G.;Moser, B.;Mackay, C. R. :|
|Publisher Name||NAT REV IMMUNOL|
|Published Date||2005-01-01 00:00:00|