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Selective stimulation of T cell subsets with antibody-cytokine immune complexes


Interleukin-2 (IL-2), which is a growth factor for T lymphocytes, can also sometimes be inhibitory. Thus, the proliferation of CD8+ T cells in vivo is increased after the injection of a monoclonal antibody that is specific for IL-2 (IL-2 mAb), perhaps reflecting the removal of IL-2-dependent CD4+ T regulatory cells (T regs). Instead, we show here that IL-2 mAb augments the proliferation of CD8+ cells in mice simply by increasing the biological activity of preexisting IL-2 through the formation of immune complexes. When coupled with recombinant IL-2, some IL-2/IL-2 mAb complexes cause massive (>100-fold) expansion of CD8+ cells in vivo, whereas others selectively stimulate CD4+ T regs. Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response.

Type Journal
ISBN 1095-9203 (Electronic)
Authors Boyman, O.;Kovar, M.;Rubinstein, M. P.;Surh, C. D.;Sprent, J. :
Publisher Name SCIENCE
Published Date 2006-01-01
Published Volume 311
Published Issue 5769
Published Pages 1924-7
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version