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Regulation of B cell self-tolerance by BAFF


To avoid the generation of pathogenic autoantibodies, self-reactive lymphocytes are deleted at several distinct checkpoints during B cell maturation. BAFF is required for mature B cell development and survival but causes B cell hyperplasia and autoimmunity when it is overexpressed. Self-reactive B cells have reduced responsiveness to BAFF and therefore die due to the limiting levels of BAFF available in vivo. Elevated BAFF expression subverts B cell self-tolerance by rescuing self-reactive B cells normally deleted relatively late during maturation. Strongly self-reactive B cells are deleted prior to expression of BAFF-R and are therefore resistant to rescue by BAFF.

Type Journal
ISBN 1044-5323 (Print)
Authors Brink, R. :
Responsible Garvan Author Prof Robert Brink
Published Date 2006-01-01
Published Volume 18
Published Issue 5
Published Pages 276-83
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version