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Cell cycle control in breast cancer cells


In breast cancer, cyclins D1 and E and the cyclin-dependent kinase inhibitors p21 (Waf1/Cip1)and p27 (Kip1) are important in cell-cycle control and as potential oncogenes or tumor suppressor genes. They are regulated in breast cancer cells following mitogenic stimuli including activation of receptor tyrosine kinases and steroid hormone receptors, and their deregulation frequently impacts on breast cancer outcome, including response to therapy. The cyclin-dependent kinase inhibitor p16 (INK4A) also has a critical role in transformation of mammary epithelial cells. In addition to their roles in cell cycle control, some of these molecules, particularly cyclin D1, have actions that are not mediated through regulation of cyclin-dependent kinase activity but may be important for loss of proliferative control during mammary oncogenesis.

Type Journal
ISBN 0730-2312 (Print)
Authors Caldon, C. E.;Daly, R. J.;Sutherland, R. L.;Musgrove, E. A. :
Published Date 2006-01-01
Published Volume 97
Published Issue 2
Published Pages 261-74
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version