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Phospholipid signalling through phospholipase D and phosphatidic acid


Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. This activity can participate in signal transduction pathways and impact on vesicle trafficking for secretion and endocytosis, as well as receptor signalling. Phospholipids can regulate PLD activity directly, through specific intermolecular interactions, or indirectly, through their effect on the localization or activity of PLD's protein effectors. This short review highlights these various phospholipid inputs into the regulation of PLD activity and also reviews potential roles for PLD-generated phosphatidic acid, particularly a mechanism by which the phospholipid may participate in the process of vesicular trafficking.

Type Journal
ISBN 1521-6543 (Print)
Authors Cazzolli, R.;Shemon, A. N.;Fang, M. Q.;Hughes, W. E. :
Publisher Name IUBMB LIFE
Published Date 2006-01-01
Published Volume 58
Published Issue 8
Published Pages 457-61
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version