A new role for CCR5 in innate immunity--binding to bacterial heat shock protein 70
CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.
|Authors||Mackay, C. R.;Sallusto, F. :|
|Publisher Name||EUR J IMMUNOL|
|Published Date||2006-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?2085_10582/06 Mackay EJICCR5 2293.pdf|