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The role of the BAFF/APRIL system on T cell function

Abstract

BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Thl)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.

Type Journal
ISBN 1044-5323 (Print)
Authors Mackay, F.;Leung, H. :
Publisher Name SEMINARS IN IMMUNOLOGY
Published Date 2006-01-01 00:00:00
Published Volume 18
Published Issue 5
Published Pages 284-9
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16931039
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2088