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Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells


High-density lipoprotein (HDL)-induced activation of the Ras/MAPK pathway can be mediated by protein kinase C (PKC)-dependent and independent pathways. Although both pathways co-exist in cells, we showed that binding of HDL to scavenger receptor BI (SR-BI) in CHO cells activates Ras and MAPK in a PKC-independent manner. We have recently identified that HDL-induced activation of Ras and Raf-1 is reduced in annexin A6 expressing CHO cells (CHOanx6). In the present study we demonstrate that despite the loss of Ras and Raf-1 activity, HDL induces MAPK phosphorylation in CHOanx6 cells. Since annexin A6 is a PKCalpha-binding protein we therefore investigated the possible involvement of PKC in HDL-induced Ras and MAPK activation in CHOanx6 cells. Taken together our findings demonstrate that HDL-induced H-Ras and MAPK activation is PKC-dependent in cells expressing annexin A6 to compensate for the loss of PKC-independent activation of H-Ras and MAPK.

Type Journal
ISBN 0898-6568 (Print)
Authors Rentero, C.;Evans, R.;Wood, P.;Tebar, F.;Vila de Muga, S.;Cubells, L.;de Diego, I.;Hayes, T. E.;Hughes, W. E.;Pol, A.;Rye, K. A.;Enrich, C.;Grewal, T. :
Published Date 2006-01-01
Published Volume 18
Published Issue 7
Published Pages 1006-16
Status Published in-print
URL link to publisher's version