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Homeostasis of memory T cells


The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common gamma chain (gammac) family of cytokines, interleukin-7 (IL-7) and IL-15, govern homeostasis of memory T cells. These two cytokines work in conjunction to support memory T-cell survival and intermittent background proliferation. Normal animals contain significant numbers of spontaneously arising memory-phenotype (MP) cells, though whether these cells are representative of true antigen-specific memory T cells is unclear. Nevertheless, it appears that the two types of memory cells do not display identical homeostatic requirements. For antigen-specific memory CD8+ T cells, IL-7 is primarily important for survival while IL-15 is crucial for their background proliferation. For memory CD4+ T cells, IL-7 has an important role, whereas the influence of IL-15 is still unclear.

Type Journal
ISBN 0105-2896 (Print)
Authors Surh, C. D.;Boyman, O.;Purton, J. F.;Sprent, J. :
Responsible Garvan Author Prof Jonathan Sprent
Published Date 2006-01-01
Published Volume 211
Published Pages 154-63
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version