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The control of bone remodeling by neuropeptide Y receptors


An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice. Subsequent studies have now demonstrated that this central pathway is distinct from that of the other centrally regulated bone formation pathway mediated by leptin. This review discusses these recent findings and outlines how these new pathways could translate into potential novel targets for the treatment of bone disease.

Type Journal
ISBN 0196-9781 (Print)
Authors Allison, S. J.;Baldock, P. A.;Herzog, H. :
Publisher Name PEPTIDES
Published Date 2007-01-01
Published Volume 28
Published Issue 2
Published Pages 320-5
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version