Cytokines and T-cell homeostasis
Homeostasis of T cells can be defined as the ability of the immune system to maintain normal T-cell counts and to restore T-cell numbers following T-cell depletion or expansion. These processes are governed by extrinsic signals, most notably cytokines. Two members of the common gamma chain family of cytokines, interleukin (IL)-7 and IL-15, are central to homeostatic proliferation and survival of mature CD4(+) and CD8(+) T cells. Recent evidence suggests that other cytokines, including IL-2, IL-10, IL-12, interferons and TGF-beta, as well as the transcription factors T-bet and eomesodermin all play important but different roles at distinct stages of T-cell homeostasis.
|Authors||Boyman, O.;Purton, J. F.;Surh, C. D.;Sprent, J. :|
|Publisher Name||CURR OPIN IMMUNOL|
|Published Date||2007-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?2169_10907/07 Boyman COI Elsevier.pdf|