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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses

Abstract

Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases, many of which dephosphorylate threonine and tyrosine residues on mitogen-activated protein kinases (MAPKs), and hence are also referred to as MAPK phosphatases (MKPs). The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. For immune cells, DUSPs regulate responses in both positive and negative ways, and DUSP-deficient mice have been used to identify individual DUSPs as key regulators of immune responses. From a drug discovery perspective, DUSP family members are promising drug targets for manipulating MAPK-dependent immune responses in a cell-type and disease-context-dependent manner, to either boost or subdue immune responses in cancers, infectious diseases or inflammatory disorders.

Type Journal
ISBN 1474-1776 (Print)
Authors Jeffrey, K. L.;Camps, M.;Rommel, C.;Mackay, C. R. :
Publisher Name NATURE REVIEWS DRUG DISCOVERY
Published Date 2007-01-01 00:00:00
Published Volume 6
Published Issue 5
Published Pages 391-403
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17473844
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2219