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Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia

Abstract

The level of somatic point mutation in immunoglobulin genes is an important prognostic indicator for patients with chronic lymphocytic leukemia (CLL). Mutation analysis presently focuses solely upon the heavy chain IGHV gene, however mutation is a stochastic process that also targets IGHD and IGHJ genes. Here, we evaluate the completeness and reliability of the reported IGHJ gene repertoire, and demonstrate the likely consequences of the inclusion of IGHD and IGHJ mutations in CLL analysis, using a dataset of 607 sequences. Inclusion of these mutations would lead to the re-classification of many sequences, which should significantly improve the prognostic value of mutation analysis.

Type Journal
ISBN 0145-2126 (Print)
Authors Lee, C. E.;Jackson, K. J.;Sewell, W. A.;Collins, A. M. :
Publisher Name LEUKEMIA RESEARCH
Published Date 2007-01-01 00:00:00
Published Volume 31
Published Issue 9
Published Pages 1247-52
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17169423
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2234