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Gata-3 and mammary cell fate


ABSTRACT: Genomic regulatory networks specify how cellular gene expression responds to external temporal and spatial stimuli, ensuring that correct cell fate decisions are made and the appropriate cell phenotypes are adopted. In mammary epithelial cells, the hierarchy of stem and progenitor cells and the genetically specified program of transcriptional activity are beginning to be elucidated and integrated. A novel role for Gata-3 in specifying and maintaining mammary cell fate has recently been identified. These reports offer an understanding of how mammary cells assume and maintain a variety of cell behaviours and functions, and how a mammary cell may potentially subvert these constraints during carcinogenesis.

Type Journal
ISBN 1465-542X (Electronic)
Authors Naylor, M. J.;Ormandy, C. J. :
Responsible Garvan Author Prof Chris Ormandy
Published Date 2007-01-01
Published Volume 9
Published Issue 2
Published Pages 302
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version