Staying alive--naive CD4(+) T cell homeostasis
The immune system must maintain a broad repertoire of naive T cells in order to respond to the diverse range of pathogens that it will encounter over the course of a lifetime. Although it is known that contact with IL-7 is crucial for the survival of naive T cells, the precise intracellular signals that mediate its effects remain obscure. An article in this issue of the European Journal of Immunology has found that IL-7 requires the coordinated action of multiple pathways to maintain naive CD4(+) T cells.
|Authors||Purton, J. F.;Sprent, J.;Surh, C. D. :|
|Publisher Name||EUROPEAN JOURNAL OF IMMUNOLOGY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17724689|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/2269|