Staying alive--naive CD4(+) T cell homeostasis
The immune system must maintain a broad repertoire of naive T cells in order to respond to the diverse range of pathogens that it will encounter over the course of a lifetime. Although it is known that contact with IL-7 is crucial for the survival of naive T cells, the precise intracellular signals that mediate its effects remain obscure. An article in this issue of the European Journal of Immunology has found that IL-7 requires the coordinated action of multiple pathways to maintain naive CD4(+) T cells.
|Authors||Purton, J. F.;Sprent, J.;Surh, C. D. :|
|Publisher Name||EUR J IMMUNOL|
|Published Date||2007-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?2269_11063/07 Purton Eur J Immunol.pdf|