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Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7


Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B cells, a cell type associated with autoimmune diseases. We generated Cxcr7(-/-) mice but found that CXCR7 deficiency had little effect on B cell composition. However, most Cxcr7(-/-) mice died at birth with ventricular septal defects and semilunar heart valve malformation. Conditional deletion of Cxcr7 in endothelium, using Tie2-Cre transgenic mice, recapitulated this phenotype. Gene profiling of Cxcr7(-/-) heart valve leaflets revealed a defect in the expression of factors essential for valve formation, vessel protection, or endothelial cell growth and survival. We confirmed that the principal chemokine ligand for CXCR7 was CXCL12/SDF-1, which also binds CXCR4. CXCL12 did not induce signaling through CXCR7; however, CXCR7 formed functional heterodimers with CXCR4 and enhanced CXCL12-induced signaling. Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4.

Type Journal
ISBN 0027-8424 (Print)
Authors Sierro, F.;Biben, C.;Martinez-Munoz, L.;Mellado, M.;Ransohoff, R. M.;Li, M.;Woehl, B.;Leung, H.;Groom, J.;Batten, M.;Harvey, R. P.;Martinez, A. C.;Mackay, C. R.;Mackay, F. :
Publisher Name PNAS
Published Date 2007-01-01 00:00:00
Published Volume 104
Published Issue 37
Published Pages 14759-64
Status Published In-print
OpenAccess Link Sierro PNAS 14759.pdf