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The Y1 receptor for NPY: a key modulator of the adaptive immune system


Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immune system. The use of Y(1) receptor-deficient mice, combined with advanced methods to investigate immune functions, have provided the solution to the problem raised by previous disparities. From results obtained using Y(1)-deficient mice (Y(1)(-/-)), we uncovered a bimodal role for Y(1) on immune cells. Y(1) expression on antigen-presenting cells (APC) is essential for their function as T cell priming elements. Conversely, Y(1) signaling in T cells plays a regulatory role without which T cells are hyper-responsive. The opposite role of Y(1) on APC and T cells has reconciled previous disparities by showing that signaling via Y(1) protects against inflammation by inhibiting T cell responses, whereas Y(1)(-/-) mice are protected in the same inflammatory models due to defective APCs.

Type Journal
ISBN 0196-9781 (Print)
Authors Wheway, J.;Herzog, H.;Mackay, F. :
Responsible Garvan Author Prof Herbert Herzog
Publisher Name PEPTIDES
Published Date 2007-01-01
Published Volume 28
Published Issue 2
Published Pages 453-8
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version