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Special regulatory T-cell review: T-cell dependent suppression revisited


The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. Cannon to right of them, Cannon to left of them, Cannon in front of them Volley'd and thunder'd Storm'd at with shot and shell, Boldly they rode and well, Into the jaws of Death, Into the mouth of Hell, Rode the six hundred (suppressionists). (Adapted from The Charge of the Light Brigade, Alfred, Lord Tennyson)

Type Journal
ISBN 1365-2567 (Electronic)
Authors Basten, A.;Fazekas de St Groth, B. :
Publisher Name IMMUNOLOGY
Published Date 2008-01-01 00:00:00
Published Volume 123
Published Issue 1
Published Pages 33-9
Status Published In-print
OpenAccess Link Basten Immunol.pdf