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Rapid pulsatile corticosterone secretion in the rat is not confirmed


We attempted to confirm and extend a previous suggestion by other workers that, in the rat, corticosterone may be released as a series of very short pulses with a period of one minute. We measured the corticosterone concentration in the blood of chronically cannulated, unanaesthetised male rats, repeatedly, at ten second intervals, for periods of up to 25 minutes while the rats were engaged in normal activity or sleep or were subject to acute or chronic stress. We could find no evidence of the proposed rapid pulsatile secretion and suggest that the earlier finding may have been artifactual.

Type Journal
ISBN 0039-128X (Print)
Authors Vining, R. F.;James, D. E.;Bennett, S. P.;Kraegen, E. W. :
Responsible Garvan Author Prof Edward Kraegen
Publisher Name STEROIDS
Published Date 1981-01-01
Published Volume 38
Published Issue 3
Published Pages 297-305
Status Published in-print
URL link to publisher's version