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Revisiting the biological roles of PAI2 (SERPINB2) in cancer

Abstract

Tumour expression of the urokinase plasminogen activator correlates with invasive capacity. Consequently, inhibition of this serine protease by physiological inhibitors should decrease invasion and metastasis. However, of the two main urokinase inhibitors, high tumour levels of the type 1 inhibitor actually promote tumour progression, whereas high levels of the type 2 inhibitor decrease tumour growth and metastasis. We propose that the basis of this apparently paradoxical action of two similar serine protease inhibitors lies in key structural differences controlling interactions with components of the extracellular matrix and endocytosis-signalling co-receptors.

Type Journal
ISBN 1474-1768 (Electronic)
Authors Croucher, D. R.;Saunders, D. N.;Lobov, S.;Ranson, M. :
Publisher Name NATURE REVIEWS CANCER
Published Date 2008-01-01 00:00:00
Published Volume 8
Published Issue 7
Published Pages 535-45
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18548086
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2330