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B cells flying solo


Systemic autoimmunity such as systemic lupus erythematosus (SLE) is associated with the loss of B-cell tolerance, B-cell dysregulation and autoantibody production. While some autoantibodies may contribute to the pathology seen with SLE, numerous studies have shown that dysregulation of T-cell function is another critical aspect driving disease. The positive results obtained in clinical trials using T-cell- or B-cell-specific treatments have suggested that cooperation between T and B cells probably underlies disease progression in many patients. A similar cooperative mechanism seemed to explain SLE developing in mice overexpressing the B-cell-activating factor from the tumor necrosis factor family (BAFF). However, surprisingly, T-cell-deficient BAFF transgenic (Tg) mice develop SLE similar to T-cell-sufficient BAFF Tg mice, and the disease was linked to innate activation of B cells and production of proinflammatory autoantibody isotypes. In conclusion, dysregulated innate activation of B cells alone can drive disease independently of T cells, and as such this aspect represents a new pathogenic mechanism in autoimmunity.Immunology and Cell Biology (2008) 86, 40-46; doi:10.1038/sj.icb.7100142.

Type Journal
ISBN 0818-9641 (Print)
Authors Groom, J.;Mackay, F. :
Published Date 2008-01-01
Published Volume 86
Published Issue 1
Published Pages 40-6
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version