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T Follicular Helper (T(FH)) Cells in Normal and Dysregulated Immune Responses

Abstract

T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (T(FH) cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T cells in lymphoid tissues. T(FH) cells are distinguishable from Th1 and Th2 cells by several criteria, including chemokine receptor expression (CXCR5), location/migration (B cell follicles), and function (B cell help). Central to the function of CD4(+) T cells is IL-21, a ""helper"" cytokine produced by T(FH) cells that potently stimulates the differentiation of B cells into Ab-forming cells through IL-21R. Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies.

Type Journal
ISBN 0732-0582 (Print)
Authors King, C.;Tangye, S. G.;Mackay, C. R. :
Publisher Name Annual Review of Immunology
Published Date 2008-07-22 00:00:00
Published Volume 26
Published Pages 741-66
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18173374
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2350