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Identification of downstream targets of estrogen and c-myc in breast cancer cells


Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are regulated by E and its downstream target c-myc, we compared transcript profiles of antiestrogens-arrested cells stimulated to reinitiate cell cycle progression by E treatment or c-myc induction. Approximately 2/3 of the probe sets significantly regulated by E (adjusted p < 0.01) increased in expression. Half of the E-regulated probe sets were also regulated by c-myc. Genes involved in cell growth, cell proliferation, and cell survival were over-represented in the E-regulated geneset. Analysis of selected candidates has identified a nucleolar protein whose expression is correlated with c-myc expression in BC cell lines. These data indicate that a significant component of E-induced mitogenesis is mediated by c-myc and that selected c-myc target genes may be surrogate markers of c-myc expression in BC.

Type Journal
ISBN 0065-2598 (Print)
Authors Musgrove, E. A.;Sergio, C. M.;Anderson, L. R.;Inman, C. K.;McNeil, C. M.;Alles, M. C.;Gardiner-Garden, M.;Ormandy, C. J.;Butt, A. J.;Sutherland, R. L. :
Publisher Name Advances in Experimental Medicine and Biology
Published Date 2008-01-01
Published Volume 617
Published Pages 445-51
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version