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The Ets transcription factor Elf5 specifies mammary alveolar cell fate

Abstract

Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. Conversely, overexpression of Elf5 in an inducible transgenic model caused alveolar differentiation and milk secretion in virgin mice, disrupting ductal morphogenesis. CD61(+) luminal progenitor cells accumulated in Elf5-deficient mammary glands and were diminished in glands with Elf5 overexpression. Thus Elf5 specifies the differentiation of CD61(+) progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development.

Type Journal
ISBN 0890-9369 (Print)
Authors Oakes, S. R.;Naylor, M. J.;Asselin-Labat, M. L.;Blazek, K. D.;Gardiner-Garden, M.;Hilton, H. N.;Kazlauskas, M.;Pritchard, M. A.;Chodosh, L. A.;Pfeffer, P. L.;Lindeman, G. J.;Visvader, J. E.;Ormandy, C. J. :
Responsible Garvan Author Prof Chris Ormandy
Publisher Name GENES & DEVELOPMENT
Published Date 2008-01-01 00:00:00
Published Volume 22
Published Issue 5
Published Pages 581-6
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18316476
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/2374