Self/non-self discrimination and the problem of keeping T cells alive
Burnet appreciated the requirement for self/non-self discrimination and presciently postulated elimination of auto-aggressive cells during early life. He could not have known that, for T cells, a limited degree of autoreactivity is beneficial for the immune system. Here, we review evidence that recognition of self-components keeps T cells alive and regulates self-tolerance.Immunology and Cell Biology (2008) 86, 54-56; doi:10.1038/sj.icb.7100139; published online 11 December 2007.
|Authors||Sprent, J.;Cho, J. H. :|
|Publisher Name||IMMUNOLOGY AND CELL BIOLOGY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18071359|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/2388|