Self/non-self discrimination and the problem of keeping T cells alive
Burnet appreciated the requirement for self/non-self discrimination and presciently postulated elimination of auto-aggressive cells during early life. He could not have known that, for T cells, a limited degree of autoreactivity is beneficial for the immune system. Here, we review evidence that recognition of self-components keeps T cells alive and regulates self-tolerance.Immunology and Cell Biology (2008) 86, 54-56; doi:10.1038/sj.icb.7100139; published online 11 December 2007.
|Authors||Sprent, J.;Cho, J. H. :|
|Publisher Name||IMMUNOL CELL BIOL|
|Published Date||2008-01-01 00:00:00|
|OpenAccess Link||https://publications.gimr.garvan.org.au/download.php?2388_10023/08 sprent ICB 86 54.pdf|