Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane--an essential step for inducible glucose entry into cells. This was associated with increased activity of AMP-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.
|Authors||Tan, M. J.;Ye, J. M.;Turner, N.;Hohnen-Behrens, C.;Ke, C. Q.;Tang, C. P.;Chen, T.;Weiss, H. C.;Gesing, E. R.;Rowland, A.;James, D. E.;Ye, Y. :|
|Publisher Name||CHEMISTRY & BIOLOGY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18355726|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/2395|