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The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease


In this review, we discuss recent progress from studies on the biology of IL-21 and the role of this cytokine in the pathogenesis of autoimmunity. Recent studies have demonstrated that IL-21 plays an important and non-redundant role in a number of autoimmune animal models indicating that IL-21 could be a common modulator of the adaptive immune response towards self-tissue constituents in diseases such as systemic lupus erythematosus, models of rheumatoid arthritis, multiple sclerosis and type-1 diabetes. Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases.

Type Journal
ISBN 1093-4715 (Electronic)
Authors Vogelzang, A.;King, C. :
Publisher Name Frontiers in Bioscience-Landmark
Published Date 2008-07-01
Published Volume 13
Published Pages 5304-15
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version