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Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis

Abstract

If gamma-carboxylation, by the vitamin K1 - cycle, of glutamate residues of bone-matrix peptides is essential for the formation of bone, the circulating levels of this vitamin might indicate the potential efficiency of this process. Methods involving HPLC with electrochemical detection have very recently been developed for assaying the low levels of vitamin K1 that occur in normal plasma. Using such methods, we found that the circulating levels of vitamin K1 in osteoporotic patients (who had sustained either spinal crush-fractures or fractures of the neck of the femur) were significantly lower than those of age-matched control subjects.

Type Journal
ISBN 0021-972X (Print)
Authors Hart, J. P.;Shearer, M. J.;Klenerman, L.;Catterall, A.;Reeve, J.;Sambrook, P. N.;Dodds, R. A.;Bitensky, L.;Chayen, J. :
Publisher Name JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Published Date 1985-01-01
Published Volume 60
Published Issue 6
Published Pages 1268-9
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3998071
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/327