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Salsolinol and dopamine in rat medial basal hypothalamus after chronic ethanol exposure


Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS) - selected ion monitoring technique using deuterated internal standards in Long Evans rats chronically exposed to ethanol for ten months. Chronic ethanol exposure produced significant increases of dopamine and salsolinol concentrations in the medial basal hypothalamus but not striatum. The data suggest that the occurrence of salsolinol in rat brain tissue is a consequence of an in vivo Pictet-Spengler cyclization.

Type Journal
ISBN 0024-3205 (Print)
Authors Myers, W. D.;Mackenzie, L.;Ng, K. T.;Singer, G.;Smythe, G. A.;Duncan, M. W. :
Publisher Name LIFE SCI
Published Date 1985-01-01 00:00:00
Published Volume 36
Published Issue 4
Published Pages 309-14
Status Published In-print