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Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver


Exposure of perfused livers of fed rats to 60 mM K+ induces rapid responses in the Ca2+-sensitive metabolic events, glycogenolysis, cytoplasmic and mitochondrial NADH/NAD ratios and octanoate oxidation. All increase within 45 s of K+ addition. Metabolic responses were not observed following K+ addition to livers perfused in the absence of added Ca2+. Movements of Ca2+ into the liver were suggested from experiments in which 45Ca2+ uptake was measured. The Ca2+ antagonists verapamil, diltiazem and Ni2+ essentially abolished changes to tissue metabolism and Ca2+ fluxes induced by K+ addition. K+-induced changes were consistent with Ca2+ channel activation.

Type Journal
ISBN 0014-5793 (Print)
Authors Taylor, W. M.;van de Pol, E.;van Helden, D. F.;Reinhart, P. H.;Bygrave, F. L. :
Publisher Name FEBS LETT
Published Date 1985-01-01 00:00:00
Published Volume 183
Published Issue 1
Published Pages 70-4
Status Published In-print