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On the stimulation of respiration by alpha-adrenergic agonists in perfused rat liver


Interactions between phenylephrine-induced oxygen consumption, lactate and pyruvate output, and urea and glucose production were examined in perfused livers from fed or 48-h-fasted rats. Within 2 min of phenylephrine infusion, oxygen consumption in perfused livers was increased by approximately 40%. Increases in oxygen consumption induced by phenylephrine were essentially abolished in the presence of carboxyatractyloside, whereas those induced by dinitrophenol were still evident. Phenylephrine-induced increases in oxygen consumption were accompanied by enhanced rates of gluconeogenesis and ureogenesis in livers from fed or 48-h-fasted animals. These data indicate that phenylephrine-induced increases in respiration in perfused rat liver may result from an enhanced rate of mitochondrial oxidative phosphorylation in response to an increased cellular energy requirement.

Type Journal
ISBN 0014-2956 (Print)
Authors Taylor, W. M.;Van de Pol, E.;Bygrave, F. L. :
Publisher Name Eur J Biochem
Published Date 1986-01-01
Published Volume 155
Published Issue 2
Published Pages 319-22
Status Published in-print
URL link to publisher's version