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The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver


Output of 14CO2 from 1-14C-labelled glutamate, 2-oxoglutarate or octanoate and from 4-methyl-2-oxo[2-14C]pentanoate was increased by more than 100% after infusion of phenylephrine into perfused livers of fed rats. Infusion of ethanol or sorbitol raised 3-hydroxybutyrate/acetoacetate ratios and decreased the output of 14CO2. Increases in 14CO2 output induced by phenylephrine were observed in the presence or absence of ethanol or sorbitol and were accompanied by elevated 3-hydroxybutyrate/acetoacetate ratios under all conditions examined. Phenylephrine had no effect on total tissue ATP/ADP ratios in livers from fed or starved rats. The data suggest that phenylephrine-induced increases in tricarboxylic acid-cycle flux do not arise from lowered matrix NADH/NAD+ or ATP/ADP ratios.

Type Journal
ISBN 0264-6021 (Print)
Authors Taylor, W. M.;van de Pol, E.;Bygrave, F. L. :
Published Date 1986-01-01
Published Volume 233
Published Issue 2
Published Pages 321-4
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version