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A novel subtype of muscarinic receptor identified by homology screening

Abstract

A new member of the protein superfamily of G-protein coupled receptors has been isolated by homology screening. By virtue of its homology with other muscarinic acetylcholine receptors and its ability to bind muscarinic specific antagonists, this muscarinic receptor subtype is designated M4. The M4 mRNA is preferentially expressed in certain brain regions. The existence of multiple receptor subtypes encoded by distinct genes in the brain has functional implications for the molecular mechanisms underlying information transmission in neuronal networks.

Type Journal
ISBN 0006-291X (Print)
Authors Braun, T.;Schofield, P. R.;Shivers, B. D.;Pritchett, D. B.;Seeburg, P. H. :
Publisher Name BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Published Date 1987-01-01
Published Volume 149
Published Issue 1
Published Pages 125-32
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3120722
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/421