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Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats


Insulin action was assessed by using the hyperinsulinemic (approximately 800 pmol/L) euglycemic clamp in rats fed equal amounts of glucose or fructose (35% of calories) for 4 wk. The glucose infusion rate required to maintain euglycemia was decreased in fructose-fed animals (14.6 +/- 1.4 vs 21.8 +/- 1.1 for glucose-fed rats, p less than 0.001) with this whole-body effect contributed to equally by an impairment in hepatic insulin action and a reduction in peripheral glucose disposal in a range of tissues. There was no difference in basal glucose turnover, energy expenditure, or postprandial blood glucose and insulin responses to the diets. In the fructose-fed rats there was an increase in fasting triglyceride levels by 2 wk. Euglycemic clamp glucose disposal correlated positively and clamp hepatic glucose output correlated negatively with fasting triglyceride levels. In summary, fructose but not glucose feeding led to impaired insulin action in both the liver and peripheral tissues, effects that may depend on antecedent circulating triglyceride levels.

Type Journal
ISBN 0002-9165 (Print)
Authors Thorburn, A. W.;Storlien, L. H.;Jenkins, A. B.;Khouri, S.;Kraegen, E. W. :
Responsible Garvan Author Prof Edward Kraegen
Published Date 1989-01-01
Published Volume 49
Published Issue 6
Published Pages 1155-63
Status Published in-print
URL link to publisher's version