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The role of receptor subtype diversity in the CNS

Abstract

The molecular characterization of neuroreceptors and voltage-gated ion channels has revealed that receptor subtype heterogeneity is a common feature of chemical and electrical signal reception. The use of distinct genes encoding receptor subtypes is a favoured mechanism for generation of this diversity. We propose that the significance of the multiplicity and diversity of signal reception proteins is to increase the information-handling capacity of neurons. This may contribute to neural plasticity.

Type Journal
ISBN 0166-2236 (Print)
Authors Schofield, P. R.;Shivers, B. D.;Seeburg, P. H. :
Publisher Name TRENDS IN NEUROSCIENCES
Published Date 1990-01-01
Published Volume 13
Published Issue 1
Published Pages 8-11
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1688675
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/637