Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

High density lipoproteins, genetic polymorphism for apo A-I and coronary artery disease


HDL cholesterol and apolipoprotein A-I are associated with the development of coronary artery disease (CAD). The presence of a PstI site polymorphism adjacent to the gene encoding apo A-I (known as P2) has also been shown to be associated with CAD but this relationship is controversial. A case control study was conducted in an Australian population to re-examine whether the rare P2 allele is associated with CAD. Data were derived from 159 cases of angiographically confirmed CAD and 99 healthy controls. The proportion of CAD cases carrying the P2 allele did not differ significantly from controls (11% versus 9%). In a multiple logistic regression model controlling for the effects of age, country of birth, hypertension and hypotensive drugs, body mass index and lipid variables, the P2 allele failed to predict significantly the presence of CAD (odds ratio 1.83; 95% confidence interval 0.65-5.19).

Type Journal
ISBN 0004-8291 (Print)
Authors Simons, L. A.;Balasubramaniam, S.;Szanto, A.;Simons, J.;Friedlander, Y.;Hickie, J. B.;Shine, J. :
Responsible Garvan Author Prof John Shine
Publisher Name Aust N Z J Med
Published Date 1991-01-01
Published Volume 21
Published Issue 3
Published Pages 330-4
Status Published in-print
URL link to publisher's version