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Genomic organization and localization of the gene encoding human preprogalanin


An approximately 35-kb region of genomic DNA encoding the human preprogalanin gene including 5' and 3' flanking sequences has been cloned and characterized. Exons and flanking introns were sequenced to determine the structural organization of the gene. The gene spans 6.5 kb, with the first exon encoding only the 5' untranslated sequence. The coding region of preprogalanin and the 3' untranslated sequence is divided into five exons. Using high-resolution fluorescence in situ hybridization, the position of the single human preprogalanin gene was localized to chromosome 11q13.3-q13.5. Several oncogenes have been mapped to this region, which is also the breakpoint for the translocation t(11;14)(q13;q32) in chronic lymphocytic leukemia and diffuse B-cell lymphoma.

Type Journal
ISBN 0888-7543 (Print)
Authors Evans, H.;Baumgartner, M.;Shine, J.;Herzog, H. :
Publisher Name GENOMICS
Published Date 1993-01-01
Published Volume 18
Published Issue 3
Published Pages 473-7
Status Published in-print
URL link to publisher's version