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Comparative effects of gold on the interactions of transcription factors with DNA


We have previously hypothesized that a mode of action of the anti-rheumatic gold salt, aurothiomalate (AuTM), is the inhibition of DNA binding by transcription factors. Studies of the progesterone receptor (PR), which has a zinc finger structure in the DNA binding domain, were consistent with this hypothesis (1). Here we show that AuTM also markedly inhibits DNA binding by the transcription factor AP-1 and has less potent effects for AP-2, NF-1 and TFIID.

Type Journal
ISBN 0379-0363 (Print)
Authors Handel, M. L.;Sivertsen, S.;Watts, C. K.;Day, R. O.;Sutherland, R. L. :
Publisher Name Agents Actions Suppl
Published Date 1993-01-01 00:00:00
Published Volume 44
Published Pages 219-23
Status Published In-print