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Mechanisms of rapid bone loss following cardiac transplantation


Rapid bone loss after orthoptic cardiac transplantation (OHTX) is a major problem; however, the mechanisms are poorly understood. To investigate these mechanisms we measured biochemical and hormonal indices of bone turnover serially in 25 patients (21 men, 4 women) after OHTX. Serum osteocalcin was reduced immediately post-OHTX (2.2 +/- 0.5 ng/ml) but rose significantly by 6 and 12 months (14.1 +/- 2.5 and 15.7 +/- 2.2 respectively). Bone resorption indices (urinary hydroxyproline/creatinine and calcium/creatinine ratios) were increased immediately post-OHTX but fell by 6 months. Serum testosterone was reduced in males but recovered towards normal values by 6-12 months. Regression analysis showed lumbar bone loss was predicted independently by the change in both serum osteocalcin and testosterone. The data suggest that bone loss post-OHTX is due to a combination of accelerated turnover and hypogonadism.

Type Journal
ISBN 0937-941X (Print)
Authors Sambrook, P. N.;Kelly, P. J.;Fontana, D.;Nguyen, T.;Keogh, A.;Macdonald, P.;Spratt, P.;Freund, J.;Eisman, J. A. :
Responsible Garvan Author (missing name)
Published Date 1994-01-01
Published Volume 4
Published Issue 5
Published Pages 273-6
Status Published in-print
URL link to publisher's version